Structure analysis of collagen-model peptides with (Pro-Pro-Gly) and (Pro-Hyp-Gly) sequence repeats
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The peptides acetyl-(Gly-3(S)Hyp-4(R)Hyp)10-NH2 and acetyl-(Gly-Pro-3(S)Hyp)10-NH2 do not form a collagen triple helix.
Hydroxylation of proline residues in the Yaa position of the Gly-Xaa-Yaa repeated sequence to 4(R)-hydroxyproline is essential for the formation of the collagen triple helix. A small number of 3(S)-hydroxyproline residues are present in most collagens in the Xaa position. Neither the structural nor a biological role is known for 3(S)-hydroxyproline. To characterize the structural role of 3(S)-h...
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The tetrapeptide Gly-Pro-Arg-Pro inhibits fibrinogen aggregation, probably by binding to the same sites used during initiation of fibrin formation. The Gly-Pro-Arg-Pro binding sites have not yet been identified. However, their possible sequence and locations have been predicted on the basis of the amino acid pairing hypothesis. One of these predicted sites is on fibrinopeptide A. We report here...
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An H1 to relax chromatin? R ed blood cell differentiation requires a stickier histone H1, which closes chromatin to transcription, based on fi ndings from Dhananjay Yellajoshyula and David Brown (University of Mississippi, Jackson, MS). The less sticky form, however, might favor transcription not by falling off faster but by relaxing chromatin. Undifferentiated cells need relaxed, accessible ch...
متن کاملOligopeptides with the sequences ala-pro-gly and gly-pro-gly as substrates or inhibitors for protocollagen proline hydroxylase.
Sequential oligopeptides prepared by condensation of peptides with the sequence Ala-Pro-Gly or Gly-Pro-Gly were examined as possible substrates or inhibitors for the synthesis of hydroxyproline by protocollagen proline hydroxylase. The tripeptide BOC-Ala-Pro-Gly-OMe (where BOC-represents 1-butoxycarboxyland Me represents methyl) was not hydroxylated, but oligopeptides ranging in size from BOC(A...
متن کاملCentral activity of peptide Gly-Pro-Hyp--the main component of collagen degradation products mixture.
The effect of tripeptide Gly-Pro-Hyp on the central nervous system was studied. The peptide Gly-Pro-Hyp is a main component of the mixture of collagen type I degradation products obtained by 6-h digestion with bacterial collagenase. The investigated peptide in the doses 1 microgram, 2 micrograms, and 5 micrograms significantly reduces the psychomotor activity of animals, intensifies haloperidol...
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ژورنال
عنوان ژورنال: Nihon Kessho Gakkaishi
سال: 1998
ISSN: 0369-4585,1884-5576
DOI: 10.5940/jcrsj.40.supplement_189